The Smallpox Hospital is located on the southern end of Roosevelt Island, East River, New York City.
The structure was originally located on the southernmost tip of the island and was surrounded on three-sides by water. In the late 1950s, however, landfill from ongoing New York City demolition projects began to be deposited in the East River, directly south of the hospital. Over the course of the next thirty years, the island grew in the southern direction by nearly five-acres. Four Freedoms Park, designed by the architect Louis Kahn, is situated on the five acres directly south of the structure.
To the north of the structure is the recently completed Southpoint Park, an 8-acre open space park with meandering walkways and native plantings.
In 2014, construction began of the Cornell Technion applied sciences and technology campus. The first phase of construction will be complete in 2017. The final campus, which will be complete in 2037, will run from the line of Queensborough Bridge to the northern edge of Southpoint Park.